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jabfm vol. 10 issue 1, 2012

Two-photon laser polymerization: from fundamentals to biomedical application in tissue engineering and regenerative medicine

Two-photon laser polymerization: from fundamentals to biomedical application in tissue engineering and regenerative medicine

J Appl Biomater Funct Mater 2012; 10(1): 56 - 66

Article Type: REVIEW

DOI:10.5301/JABFM.2012.9278

Authors

M.T. Raimondi, Manuela T. Raimondi, Shane M. Eaton, Shane M. Eaton, Michele M. Nava, Michele M. Nava, Matteo Laganà, Matteo Laganà, Giulio Cerullo, Giulio Cerullo, Roberto Osellame

Abstract

Three-dimensional material microstructuring by femtosecond laser-induced two-photon polymerization is emerging as an important tool in biomedicine. During two-photon polymerization, a tightly focused femtosecond laser pulse induces a crosslinking photoreaction in the polymer confined within the focal volume. As a rapid-prototyping technique, two-photon polymerization enables the fabrication of truly arbitrary three-dimensional micro- and nano-structures directly from computer models, with a spatial resolution down to 100 nm. In this review, we discuss the fundamentals, experimental methods, and materials used for two-photon polymerization; in addition, we present some applications of this technology related to microfluidics and to biomaterial scaffolds for tissue engineering and regenerative medicine.

Article History

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Authors

  • Raimondi, M.T. [PubMed] [Google Scholar]
    LaBS, Department of Structural Engineering, Politecnico di Milano, Milano - Italy
  • Raimondi, Manuela T. [PubMed] [Google Scholar]
    LaBS, Department of Structural Engineering, Politecnico di Milano, Milano - Italy
  • Eaton, Shane M. [PubMed] [Google Scholar]
    Institute of Photonics and Nanotechnologies, Consiglio Nazionale delle Ricerche (IFN-CNR), Milano - Italy
  • Eaton, Shane M. [PubMed] [Google Scholar]
    Institute of Photonics and Nanotechnologies, Consiglio Nazionale delle Ricerche (IFN-CNR), Milano - Italy
  • Nava, Michele M. [PubMed] [Google Scholar]
    LaBS, Department of Structural Engineering, Politecnico di Milano, Milano - Italy
  • Nava, Michele M. [PubMed] [Google Scholar]
    LaBS, Department of Structural Engineering, Politecnico di Milano, Milano - Italy
  • Laganà, Matteo [PubMed] [Google Scholar]
    LaBS, Department of Structural Engineering, Politecnico di Milano, Milano - Italy
  • Laganà, Matteo [PubMed] [Google Scholar]
    LaBS, Department of Structural Engineering, Politecnico di Milano, Milano - Italy
  • Cerullo, Giulio [PubMed] [Google Scholar]
    Department of Physics, Politecnico di Milano, Milano - Italy
  • Cerullo, Giulio [PubMed] [Google Scholar]
    Department of Physics, Politecnico di Milano, Milano - Italy
  • Osellame, Roberto [PubMed] [Google Scholar]
    Institute of Photonics and Nanotechnologies, Consiglio Nazionale delle Ricerche (IFN-CNR), Milano - Italy

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